Saturday, March 14, 2020

germ line gene therapy essays

germ line gene therapy essays Whether it is referred to by its scientific term "syngamy" or by the general term "conception", the moment a sperm cell unites with an egg cell stirs, both in the scientist and the layperson, much awe and reverence. It is the point at which a new and unique genome is created. To some it is the instant a new person comes into existence. Such a union has been repeated for billions of years since its advent in the first, simple organisms. It is a means by which evolution can exert its influence. When the genetic material of two individuals combine in sexual reproduction, any variations between the two inherited sets of genes may result in offspring that are more or less suited to its environment. Human beings have come to a point in this process where we can now, to an extent, shape the environment to suit our needs. The evolution of intelligence in our specie is the characteristic that has had the most profound impact on our planet and on us. This intelligence, among other things, allows us to understand and combat some genetic diseases. Inventions such as spectacles to correct our vision or drugs that fight heart disease and cancer have extended and improved the lives of individuals who, in a more Darwinian world, would have otherwise been eliminated by natural selection. Cheating this process, however, has allowed a multitude of genetic diseases such as Tay Sachs and hemophilia to propagate in our gene pool. But researchers are taking the field of medicine to a new frontier that promises to eliminate genetic diseases. New technology is being developed that will allow scientists to alter or replace defective genes in germ-line cells (egg and sperm cells). In a literal sense it will allow us to control the evolution of our specie as these alterations may be passed on from generation t o generation. The implications are profound for the individual and for society. Above it all the specter of eugenics, the process of se...

Wednesday, February 26, 2020

Letter of Intent Essay Example | Topics and Well Written Essays - 1000 words

Letter of Intent - Essay Example The researcher states that admission into McGill's Counseling Psychology program will not only fulfill the career ambitions, it will also fulfill the purpose in life. The researcher would like to devote his energies to showcase the effects of parenting on a child's overall development. It is a subject that the researcher naturally holds close to his heart. McGill University has been his preferred university since he was 16 years old, living in Malaysia. At the time, the author was looking at education options while planning to run away to Canada as a naive teen. The McGill University with its prestigious accolades, facilities and student life, was an easy winner. Since then, the author has always wanted to study at McGill and now armed with a Psychology degree from New Zealand, the next step is clear. The researcher picked Counseling Psychology because he wants to be out on the field working with people. Besides being able to work with some of the most respected psychologists in this program, the author is drawn to the non-thesis aspect of it. The researcher is happiest when the assessment is continuous and hands-on performance is evaluated - he performs at his peak that way as he likes taking challenges head-on. In addition, the author is attracted to the certification as a counselor one receives at the end of the program, with the option of doing a Ph.D. later on. Currently, he is volunteering as a childcare facilitator at the Young Parents Program in NDG and as a research aide at the Talwar's Research Center at McGill. Along with that, the author is also working as a freelance writer to save up for his post-grad fund. Prior to this, the author was an international student mentor in his alma maters where he provided mentoring, guidance and English language aid to students from China and Japan. The researcher really loves working with people and he enjoys being a positive part of their life. The researcher confesses that his time as an international student me ntor was the happiest moments of his life. It was a start to the discovery of his career path to be a counselor. Although the author may not have stellar results like some of his peers, he has a lot to offer in terms of his personal interest, future plans in this field and the will to accomplish whatever it takes to make this ambition work. The researcher is prepared to work extremely hard to get to where and what he wants. He is even proud of his apparently meager accomplishments because at one point in time, graduating itself had seemed a tall order for him. To cut a long story short, the author had not been making the right choices in life but he has since bounced back. The researcher has learned through the counsel of one very remarkable lecturer that the choices in life are mine to make, and mine to live with, regardless of the circumstances or his upbringing. The researcher is taking that advice again as he is writing this letter. The researcher is making the choice to seek en trance in one of the toughest programs at McGill University because he knows he is worth it.

Monday, February 10, 2020

There are many popularly suggested business objectives, while Essay

There are many popularly suggested business objectives, while academically the objective to maximise shareholder wealth is considered superior. Discuss. (In y - Essay Example Despite these claims, research suggests that maximizing shareholder wealth is considered superior to all objectives. Wal-Mart claims to hold down inflation in the US (Fishman, 2003), create jobs, and has customer-centered strategy as their prices are unbeatable, but they ultimately squeeze the vendors and under-pay the staff (Heyer, 2005) with the ultimate goal of maximizing shareholder wealth. They even have an efficient supply chain and source their products from developing countries and claim to be a part of their growth. Nevertheless, employee wages at Wal-Mart are as much as 31% lower than competitors (Nester, 2006). It pays practically no benefits and very often employees have to work overtime without any additional compensation. Wal-Mart ranked fourth in terms of social responsibility in terms of its dealings with its stakeholders but there were 4851 claims filed against it in the court (Papasolomou-Doukakis, Krambia-Kapardis & Katsioloudes, 2005). Corporate giants like the CEO of Coca-Cola too make tall claims that by being more efficient and more profitable, it makes businesses better for the community (Ash, 2004) but findings reveal otherwise. They have committed as many as 179 major Human Rights violations (Cairns, 2005). The union leader was shot dead at the Columbia bottling plant. Turkish and Indonesian workers face mass firings for their union activity. Multination Monitor, an American non–profit organization, listed coke amongst the worst ten companies in US. In India they are diverting potable water from local residents for the production of soft drinks. During the processing of soda pop in India, Coke has contaminated soil and underground water with toxic cadmium, which was found in the sludge. They have also been charged and found guilty of bribing the Pollution Control Board in South India. They are accused of inflating profits, selling contaminated beverages and violating contracts. Under the garb of commu nity

Thursday, January 30, 2020

Sole Proprietorship Essay Example for Free

Sole Proprietorship Essay †¢Liability is unlimited. The owner or sole proprietor is legally responsible for all debts, law suit settlements and contract fulfillments. Though insurance policies can be purchased to protect against unforeseen events, a judgment decree or balance exceeding the purchased plan amount could come directly out of the personal assets of the owner including but not limited to personal home, bank accounts, college funds or other tangible assets. †¢Income Taxes for sole proprietorship act no differently than paying standard income tax. The IRS sees no distinction between the sole proprietor and the owner’s personal finances. A standard 1040 form will be prepared yearly including a schedule C or C-EZ form for profit disclosure. Tax rate will vary year to year depending on the net profits of the business. †¢Longevity is limited to the lifetime of the owner or the completed sale of the company’s tangible and intangible assets to an individual or outside entity †¢If the owner dies without selling, the business ceases to exist. †¢Control is the most appealing factor for Sole Proprietorships as the owner needs only answer to themselves. The owner makes all decisions for the day to day operations of the company including entering into contracts, handling finances, hiring employees and even at will dissolution of the company. †¢Profit retention is a key factor that distinguishes Sole Proprietorship over all other business forms. The owner retains all profits for their own. They have no legal obligation to share the profits with any one. Please note that this does not grant the owner clemency from paying their debts or obligations if profits are low for any given length of time. †¢Location can be anywhere but is registered on a state level and must abide by local state laws. If distributing goods to other states than the registered state of the business other tax implications come in to play such as whether sales tax must be applied.

Wednesday, January 22, 2020

Sassouma Berete and Sogolon Kedjou in The Epic of Sundiata Essay

Mothers play a very influential role in a young mans life. Even though Sogolon Kedjou and Sassouma Bà ©rà ©tà © both had an impact on there son's life, their character traits were at different ends of the maternal spectrum. Despite minuscule similarities Sogolon Kedjou and Sassouma Bà ©rà ©tà © were depicted in direct contrast in the epic Sundiata. When comparing the two Sogolon Kedjou and Sassouma Berete both did what they thought would help to get their son's to become king. Sogolon knew everything that Sassouma was capable of doing to hurt her family, so she came up with the idea to leave the kingdom. Soglon said, "Lets us leave my son" (113). She thought this would be the best thing to do for all her children so she could keep them alive. "Despairing of ever injuring you, Sassouma will aim her blows at your brother or sister"(115). Although it was Sundiata's destiny to become king there was no set time placed on when this would occur. Therefore traveling to different kingdoms gave them time, and allowed for the fulfillment of not only Sundiata's destiny, but the destiny of his sibling too. Sassouma on the other hand wanted her son Dankaran to reign as the king of Mali after his father passed away. Sassouma knew her late husband would not pass the throne to her son, so she decided to banish Sogolon and her family to the backyard. Sassouma thought this would help her son's path to becoming the next king of Mali. She thought Sundiata was competition and a distraction to her son, so she wanted him dead. "I want to kill Sundiata. His destiny runs counter to my son's and he must be killed while there is still time" (115). Although Sogolon and Sassouma Berete were both wives and mothers, Sogolon was portrayed as a good mother... ... to mine" (111). From this quote, it clearly shows how much arrogance and vanity the queen really had. In contrast to this, and despite the intense humiliation that she went through, Sogolon humbly left Sassouma's home "with a lump in her throat."(111) She never talked back to Sassouma, and she would never let Sassouma see her cry. Since Sogolon and Sundiata let his fait play out, they ended up on top. Sundiata takes his rightful place and becomes the king of Mail which he was born to lead. In conclusion, despite minuscule similarities Sogolon Kendjou and Sassouma Berete were depicted in direct contrast in the epic Sundiata. It is obvious that, despite the fact that both queens wanted the best for their sons, their characters and methods were different. Since they were so different it influenced not only Sundiata and Dankaran but all of the king's children.

Tuesday, January 14, 2020

Disposal of Offal and Environmental Concerns Essay

People complain about the much slower disposal of offal and other animal waste thrown uncovered in the midst of residential areas after sacrificing of hundreds of thousands of animals by the citizens as the necessary ritual of Eid ul Azha. Such highly random throwing of animal waste could cause an outbreak of infectious diseases anytime in the overcrowded residential areas. Dwellers of various parts of the country had been pinning great hopes to the revival of town administrations, after the gap of a long time, for resolution of their long-pending municipal and civic problems, especially unattended piles of garbage nearby to densely populated residential areas, posing serious health hazards to their residents. Town administrations claim to have made effective arrangements for the removal of offal and cleanliness during Eid ul Azha. The concerned public quarters said that the sanitation and cleanliness situation had been a lot better in residential areas. In several instances, especially in far-flung areas, offal and other animal waste remained unattended in open grounds and alleys from dawn to dusk. In some brazen incidents, the stray dogs and scavenger birds were found tearing up and devouring upon these openly thrown pieces of offal and other parts of animal waste, creating serious health and civic problems. In some areas civic situation had been already pathetic with sewage overflowing on several of the major roads of city and with these scattered unattended offal and other parts of animal waste, the situation has been quite messy in the area with the passage of Eid ul Azha days. In several residential parts, people on self-help basis and privately hiring the services of sweepers disposed of offal and other animal waste and also undertook health preventive measures as till late evening there had been no disposal work by the town administration. Management practices -an overview: Appreciable practices: * Every town administration had designated its own offal collection and dumping points for proper disposal of offal and animal waste. These trenches for disposal of offal would be filled after the third day of Eid ul Azha. * Extensive insecticide fumigation and aroma spray carried out in residential areas to prevent the outbreak of contagious diseases and ameliorate the civic and sanitation situation in major residential areas of the city. * The management has failed to dispose of the intestines, offal and carcasses of sacrificial animals the jurisdiction during the Eid ul Azha. * A visit revealed that sanitary workers of the civic body did not bother to clean the areas of scattered entrails of the sacrificial animals, which were still lying along the main road. * The management before the Eid-ul-Azha had divided the city into zones for effective implementation of the action plan, especially prepared for cleanliness. * To keep the city clean and remove remains of the sacrificial animals cancellation of leaves of the Sanitation staff was announced to work round-the-clock in three shifts. * In many major cities the authorities made deep ditches for the proper disposal of the of offal and animal flashes while Lime powder also being sprinkled and applied to garbage trolleys and sacrificial places to avoid pollution and rush of birds. * The vehicles and staffers used by the Town administration for emergency duties for disposing of offal after sacrificing of animals, proved to be too less in numbers given the heavy volume of task. Malfunctioning of administration: * The inhabitants have been urging the administration high-ups to ensure cleanliness of the entire city on emergency basis to avoid nauseating odor and related problems. * It was also observed that in most parts of the capital city excluding posh areas people have not thrown the offal and other wastage of sacrificial animals at prescribed places. * The improper disposal of offal and wastes is not only polluting the environment but also disturbing the aerial traffic in the airspace near the airport. After the slaughtering of animals near railway tracks, the intestines, offal and other wastes need attention of the authorities to prevent people from spreading pollution in jurisdiction of airports and cant areas. * Birds pose a safety threat to airplanes, especially during landing and take-off. When birds strike an aircraft traveling at high speed, the impact can sometimes be dangerous. Despite Pakistan Air Force (PAF) awareness campaign before Eid, the locals as well as the municipal staff could not ensure quick and safe disposal of the remains of the sacrificial animals in the jurisdiction of the airport. * The surrounding area’s pollution attracted birds and causes problems to the pilot. The removal of dirty flashes and meet of animal from the sites of slaughtering centers is direly needed in order to avoid any misshape. * Some residents throwing the animals` waste into narrow drains, causing stringent smell in their locality. * Suburbs were specially ignored by the sanitary workers of the civic body where remains of the sacrificial animals had created serious problems for residents. The Irony: The reckless attitude of the local municipal administration and residents not caring for cleanliness could also cause diseases. There is severe need that municipal administration should ensure that the waste of each animal should be dumped in deep ditches to avoid pollution as well as rush of birds toward slaughtering sites in the city. Those people who violate law and leaving animal wastes on open surface of the earth must be charges with heavy fine to forces them to keep the environment clean. Measures to be taken: * A consolidated strategy should be adopted on the occasion of Eid-ul-Azha for sanitary arrangements and disposal of offal of sacrificial animals. * Cleanliness is an article of faith and as a nation, it is a collective responsibility to keep the surroundings clean. * Cleanliness arrangements should be ensured on Eid as well as Taroo and Maroo at any cost and stern action should be taken against the persons burning â€Å"Siri Paays† (head and feet of sacrificial animals) on the roadsides as it causes environmental pollution. * The administrative officers and officials displaying negligence towards sanitary arrangements during Eid days will not be spared. * Ban on the sale and purchase of sacrificial animals in the city should be strictly implemented and this business should be carried out only at the points specified for this purpose. * A vigorous public awareness campaign should be launched for maintaining cleanliness during the Eid days and disposal of animals waste and the assembly members should personally supervise the Eid arrangements. * The Chief Minister directed that complaint cell regarding cleanliness arrangements should be activated and it should work round the clock to redress public complaints. * Modern technology should be utilized for the supervision of the sanitary staff and planning should be made for this purpose with the assistance of Information and Technology Board. * Volunteers should also be deputed for sanitary arrangements on the occasion of Eid. * Special bags should be given to the citizens for disposal of animal waste while special centers should also be established for the collection of offal from where it will be taken and destroyed at specific places in a proper manner. References: 1. http://www.thenews.com.pk/Todays-News-4-140017-Slow-disposal-of-offal-irks-residents-in-many-areas 2. http://www.brecorder.com/general-news/172/1252726/

Monday, January 6, 2020

Risk Management Term Project - 1616 Words

Risk Management Term Project - CE 592 Dr. Jaselskis Spring 2015 Colby Meador Erik Messina Table of Contents 1. Introduction 2. Five Step Process 2.1. Risk Management Plan 2.2. Identifying Risks 2.3. Analyze Project Risks 2.4. Plan Responses for Project Risks 2.5. Monitor Risks 3. Significant Risks 4. Pros/Cons of Risk Managment 5. Triple Contrain 6. Topic Specific vs. All Inclusive 7. Conclusion 8. References 1. Introduction Risks are an inherent part of everything in life, but it is how we plan and prepare for them that determines the ultimate effect they have on us. We invest money in health insurance plans for when we get sick and invest time in preparing for exams should we encounter any difficult problems, so it definitely makes since to account for risk when it comes to construction projects. It is our endeavor to examine the topic of risk management from the construction viewpoint to gain a better understanding of its significance and what it encompasses. The realistic definition of risk is â€Å"any uncertain event or condition that, if it occurs, has a positive or negative effect on a project’s objectives† (Project Management Institute, 2008). Since risk is associated with uncertainty, it should be appropriately planned for in the early stages of the project. Risk is inherent with any project and should be assessed continually while simultaneously developing plans to address them. Different types of risk we expect toShow MoreRelatedTerm Paper on Project Risk Management14904 Words   |  60 PagesCHAPTER 1 INTRODUCTION 1.1 INTRODUCTION Project management is the application of knowledge, skills, tools, and techniques to project activities in order to meet or exceed stakeholder needs and expectations from a project. Project risk management includes the processes concerned with identifying, analyzing, and responding to project risk. It includes maximizing the results of positive events and minimizing the consequences of adverse events. 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